VERNAKALANT HYDROCHLORIDE

中文名	VERNAKALANT HYDROCHLORIDE
英文名	VERNAKALANT HYDROCHLORIDE
别名	盐酸维那卡兰盐酸弗纳卡兰盐酸维纳卡兰化合物 T17227
英文别名	D06665 Vernakalant HCl RSD1235 hydrochloride RSD 1235 hydrochloride RSD-1235 hydrochloride VERNAKALANT HYDROCHLORIDE Vernakalant hydrochloride (usan) Vernakalant ((3R,1'R,2'R)-Isomer) HCl
CAS	748810-28-8
化学式	C20H32ClNO4
分子量	385.93
熔点	151-153oC
溶解度	DMSO (微溶) 、甲醇 (微溶)
存储条件	Hygroscopic, Refrigerator, under inert atmosphere
外观	固体
颜色	White to Pale Yellow
体外研究	Block of Kv1.5 by Vernakalant Hydrochloride is mediated after channel activation, because Vernakalant causes a relatively rapid onset of block of channel current upon depolarization but little evidence of resting or “tonic” block of the channel. In the presence of 10 μM Vernakalant, rapid block is apparent after channel opening, and a steady-state current level is rapidly reached. The most important effect is the reduction in potency for Vernakalant centered at I502A, which had an IC 50 of 329±19 μM (n=4-10), compared with a control IC 50 of 13.4±0.9 μM (n=5-23), which is a 25-fold decrease in potency. V505A, I508A, T480A, and C500A showed lesser reductions in potency on Kv1.5, of between 3- and 4-fold. I508Y in our experiments increased the IC 50 for Vernakalant on Kv1.5 to 24.7 μM, again similar to the reported value for hERG.

VERNAKALANT HYDROCHLORIDE - 配置溶液浓度参考

	1mg	5mg	10mg
1 mM	2.591 ml	12.956 ml	25.911 ml
5 mM	0.518 ml	2.591 ml	5.182 ml
10 mM	0.259 ml	1.296 ml	2.591 ml
5 mM	0.052 ml	0.259 ml	0.518 ml

最后更新：2024-01-02 23:10:35

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产品名: 盐酸维那卡兰去供应商网站查看询盘
CAS: 748810-28-8
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包装: 1mg /瓶
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产品名: 盐酸维那卡兰去供应商网站查看询盘
CAS: 748810-28-8
产地: 中国上海
包装: 5mg
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产品名: Vernakalant Hydrochloride 去供应商网站查看询盘
CAS: 748810-28-8
产地: 上海
规格: V877542
价格: 25mg-4292,10mg-2342,5mg-1497,2mg-778,100mg-13412,1ml-1329
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产品名: VERNAKALANT HYDROCHLORIDE 去供应商网站查看询盘
CAS: 748810-28-8
产地: 上海
规格: 98%
价格: 5mg 1950,10mg 3200
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